School of Medicine

Wayne State University School of Medicine

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Sreenivasa R. Chinni, Ph.D.
Associate Professor
Wayne State University - School of Medicine
Scott Hall, 9200
540 E. Canfield
Detroit, MI 48201
Phone: (313) 577-1833
Biography

My long-term research interest is to understand molecular and biological signaling pathways contributing to prostate cancer metastasis. My post doctoral study focused on the chemopreventive effects of natural compounds on proliferative signaling pathways on prostate cancer growth. Subsequently, I expanded my research into prostate cancer bone metastasis with emphasis on understanding biological significance of chemokine receptor expression and signaling pathways contributing to prostate cancer bone metastasis. Our current emphasis is on how oncogenic signaling pathways drive the expression of chemokine receptor gene expression in tumor cells and in this context we found that recently identified androgen responsive Ets transcription factor fusion genes expressed in prostate cancer patients regulates chemokine receptor expression in prostate cancer cells.

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Professional Experience

Professional Memberships and Awards

  • 1983 Outstanding Senior Zoology Award.
  • 1986 Junior Research Fellowship, Department of Science and Technology, Govt. of India.
  • 1991 Homberger Fellowship, Department of Biochemistry, University of Louisville.
  • 1994 Associate Member, American Association of Cancer Research.
  • 1999 Deans Distinguished Postdoctoral Fellow.
  • 2001-2002 American Institute of Cancer Research Fellow.

Study Section Assignments

  • 2007 Henry Ford Health Systems, expert reviewer for the Internal Grant Program.
  • 2007 - 2009 DOD Prostate cancer Idea, Pre-idea -New investigator, Synergistic Idea awards. Breast cancer Idea and Postdoctoral fellowship awards, 3 sessions.
     
Publications
  • Glyzyrin AL, Chinni SR, Alhasan S, Adsay VN, Vaitkevicius VK and Sarkar FH. Molecular mechanism(s) of actinomycin-D induced sensitization of pancreatic cancer cells to CD95 mediated apoptosis. Int J Oncol. 20(1):201-5, 2002.
  • Chinni SR and Sarkar, FH. Akt inactivation is a key event in Indole-3-Carbinol (I3C) induced apoptosis of PC-3 cells. Clin. Can. Res 8(4):1228-36, 2002.
  • Chinni SR, Alhassan SA, Multani, AS, Pathak, S and Sarkar FH. Pleotropic effects of genistein on MCF-7 breast cancer cells. Int J Mol Med. 12(1):29-34, 2003.
  • Li Y, Chinni SR and Sarkar FH. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells. Front Biosci.10:236-43, 2005.
  • Dong Z, Bonfil RD, Chinni SR, Deng X, Trindade Filho JC, Bernardo M, Vaishampayan U, Che M, Sloane BF, Sheng S, Fridman R and Cher ML. Matrix metalloproteinase activity and osteoclasts in experimental prostate cancer bone metastasis tissue. Am J Pathol. 166(4):1173-86, 2005.
  • Chinni SR, Sivalogan S, Dong Z, Filho JC, Deng X, Bonfil RD and Cher ML. CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12. Prostate. 66(1):32-48, 2006.
  • Bonfil, R. D., Sabbota, A., Nabha, S., Dong, Z., Meng, H., Yamamoto, H., Chinni, SR., Bernardo, M. M., Lim, I. T., Chang, M., Filetti, L. C., Mobashery, S., Cher, M. L., Fridman, R. Inhibition of human prostate cancer growth, osteolysis and angiogenesis in a bone metastasis model by a novel mechanism-based selective gelatinase inhibitor International Journal of Cancer. 118:2721-2726, 2006.
  • Bonfil, R. D., Dong, Z., Trindade Filho, J. C., Osenkowski, P., Nabha, S., Chinni, S.R., Yamamoto, H., Sabbota, A., Vessella, R. L., Fridman, R., Cher, M. L. Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Promotes Tumor Growth and Bone Degradation in Prostate Cancer Bone Metastasis. American Journal of Pathology 170(6):2100-11, 2007.
  • Deng, X., Bhagat, S., Dong, Z., Mullins, C., Chinni, S.R., Cher, M.L. Tissue inhibtor of metalloproteinase-3 induces apoptosis in prostate cancer cells and confers increased sensitivity to paclitaxel. Eur. J. Cancer. 42(18):3267-3273, 2007.
  • Yamamoto, H., Bonfil, R.D., Wiesner, C., Nabha, S., Dong, Z., Meng, H., Saliganan, A., Sabbota, A., Chinni, S.R., Cher, M.L. Quantitative assessment of small intraosseous prostate cancer burden in SCID mice using fluorescence imaging. Prostate. 67(1):107-114, 2007.
  • Bonfil, R. D., Chinni, S. R., Fridman, R., Kim, H-R., Cher, M. L. Proteases, growth factors, chemokines, and the microenvironment in prostate cancer bone metastasis. Urologic Oncology. 25:407- 411, 2007.
  • Chinni, S.R., Dong Z, Hamilto Y, Bonfil RD and Cher ML. CXCL12/CXCR4 trans-activates HER2 in lipid rafts of PC cells and promotes in vivo intra-osseous tumor growth. Molecular Cancer Research. 6(3):446-457, 2008.
  • Aneja R., Miyagi, T., Karna, P., Ezell, T., Shukla, D., Gupta, M. V., Yates, C., Chinni, S.R., Zhau, H., Chung, L.W.K. and Joshi, HC. A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells. European Journal of Cancer. 46(9):1668-78., 2010.
  • Parajuli P, Joshee, N, Chinni, S.R., Rimando, A.M., Mittal, S, Yadav, AK. Delayed growth of glioma by Scutellaria flavinoids involves inhibition of Akt, GSK-3 and NH-kB signaling. J. Neuro-oncol, 101(1):15-24, 2010.
  • Cai, J., Kandagatla, P., Singareddy, R., Kropinski, A., Sheng, S., Cher, M.L., and Chinni, S.R. Androgens Induce Functional CXCR4 via ERG Factor Expression in TMPRSS2-ERG Fusion Positive Prostate Cancer Cells. Translational Onclology. 3(3):195-2003, 2010.